Figure 1. The extraction, separation, purification and structure identification of CYPs.
| Journal of Food Bioactives, ISSN 2637-8752 print, 2637-8779 online |
| Journal website www.isnff-jfb.com |
Review
Volume 28, December 2024, pages 24-30
Research progress on the regulation of gut microbiota by Chinese yam polysaccharides
Figure
Table
| Prebiotic benefits | Polysaccharide names | Experimental model | Polysaccharide doses | Mechanism | References |
|---|---|---|---|---|---|
| Anti-IBD | CYP-1 | LPS-induced Raw 264.7 cells and DSS-induced colitis mice | 31.25 μg/mL, 62.5 μg/mL, 125 μg/mL, 250 μg/mL, 500 μg/mL, and 300 mg/kg | Colonic pathological damage↓, NF-κB signaling pathways and NLRP3 inflammasome↓, mRNA expression of junctional proteins (claudin-1, occludin, ZO-1, connexin-43) ↑, Alistipes, Helicobacter, Enterobacteriaceae↓ | (Li, et al., 2020) |
| CYP | DSS-induced mice UC model | 200 mg/kg | Colitis symptoms, IL-10, mucin MUC-2, ZO-1 and occludin, SCFAs↑, IL-1β, TNF-α, MPO activity, LBP and ET in serum, oxidative stress in liver↓, Alistipes, Bacteroides↑ | (Lu, et al., 2023) | |
| DP | DSS-induced UC in mice | 400 mg/kg | Colonic antioxidant capacity↑, Acetatifactor, Lachnospiraceae, Lactobacillus, and Firmicutes/Bacteroidetes↑ | (Zhang, et al., 2023) | |
| CYP-3a | DSS-induced Caco-2 cells | 50 μg/mL, 100 μg/mL, and 200 μg/mL | Number of DSS-induced Caco-2 cells↓, Endoplasmic reticulum stress-mediated apoptotic pathway↓, TNF-α, IL-6, GRP78, CHOP and NF-κB↓ | (Ren et al., 2024) | |
| CYP and inulin | TNBS-induced colitis rat model | 300 mg/kg | Colitis inflammation, oxidative stress, cell motility, and signal transduction↓, Basic metabolism↑, SCFAs-producing bacteria, lactic acid-producing bacteria↑, Bacteroides, Proteobacteria and sulfate-reducing bacteria↓ | (Cai, et al., 2019) | |
| Anti-obesity | CYP | High-fat diet (HFD)-induced obese C57BL/6J mice | 100 mg/kg, 200 mg/kg and 400 mg/kg | SCFA-producing bacteria Lachnospiraceae, Lachnospiraceae_NK4A136_group, and Ruminococcaceae_UCG-014↑, Desulfovibrionaceae and Ruminococcus↓, Arginine, propionylcarnitine, and alloisoleucine↓ | (Feng, et al., 2024) |
| CYP | HFD-induced obesity C57BL/6 mice | 10 mg/kg,20 mg/kg | LDL, total cholesterol↓, IL-10, IL-1β, leptin in serum, MMP-3 and NF-κB (P65)↓ | (Cheng, et al., 2019) | |
| Immune regulation | DOP-2 | LPS-induced RAW264.7 cells and Cyclophosphamide (CTX)-treated mice | 10 μg/mL, 50 μg/mL, 100 μg/mL, 250 μg/mL, 500 μg/mL, 200 mg/kg, 400 mg/kg, and 800 mg/kg | NO, IL-6, TNF-α, body weight, the degree of injury to the immune organ index, and SCFAs↑ | (Li, et al., 2024) |
| SCYP | Cyclophosphamide (Cy)-treated mice | 50 mg/kg,100 mg/kg and 200 mg/kg | Colon contents digestive enzyme activities↑, SCFAs↑, Lactobacillus, Bacteroidetes, Akkermansia↑, Proteobacteria, Verrucomicrobia↓ | (Huang, et al., 2021) | |
| Anti-inflammatory | CYP | LPS-stimulated coculture Caco-2/Raw264.7 cells | 100 μg/mL | SCFAs↑, Bifidobacterium, Megasphaera↑, Intestinal tight junction ZO-1 and Occludin↑, NO/iNOS, TNF-α, and IL-1β↓ | (Bai, et al., 2023) |
| CYP, SCYP | LPS-induced acute Inflammation in male C57BL/6J mice | 100 mg/kg | Plasma IL-6, TNF-α↓, hepatic IL-6, IL-1β, TNF- α↓Bacteroidetes, Firmicutes↑, Proteobacteria, Desulfovibrio↓CYP increased Prevotella, SCYP increased Coprococcus | (Wu, et al., 2023) | |
| Anti-AAD | YP | Ampicillin antibiotic-associated diarrhea (AAD) Balb/c mice | – | Severe diarrhea↑, body weight loss, cecum expansion↓, Bifidobacteria, Lactobacilli↑, Clostridium perfringens, Enterococcus↓ | (Zhang, et al., 2019) |