Journal of Food Bioactives, ISSN 2637-8752 print, 2637-8779 online
Journal website www.isnff-jfb.com

Original Research

Volume 28, December 2024, pages 68-75

Formation mechanism of an inclusion complex of lenthionine with α-cyclodextrin and enhancement of its bioavailability

Figures

Figure 1.
Figure 1. Schematic diagram of α-CD structure.
Figure 2.
Figure 2. Reaction of lenthionine with α-CD. Values are means ± SE of 3 different experiments.
Figure 3.
Figure 3. DOSY-NMR spectra of the lenthionine/α-CD inclusion complex.
Figure 4.
Figure 4. 1H NMR spectral data of α-CD and the lenthionine/α-CD inclusion complex.
Figure 5.
Figure 5. Amount of lenthionine released from the inclusion complex with α-CD. Values are presented as means ± SE of 3 different experiments. Bars with different letters indicate significant differeneces at p < 0.01 according to Tukey-Kramer test.
Figure 6.
Figure 6. Time-dependent changes in the inhibitory effect of the lenthionine/α-CD inclusion complex on platelet aggregation after oral administration. Values are presented as means ± SE of 5 different experiments. * represents a significant difference from the 0-h group at p < 0.01.
Figure 7.
Figure 7. Dose-dependent changes in the inhibitory effect of the lenthionine/α-CD inclusion complex on platelet aggregation after oral administration. Values are presented as means ± SE of 5 different experiments. * represents a significant difference from the 0-mg/kg group at p < 0.01.

Table

Table 1. Chemical shifts (δ) of α-CD and the lenthionine/α-CD inclusion complex
 
Chemical shift δ (ppm)
H1H2H3H4H5H6
α-CD5.0103.5793.9293.5353.7633.854
Lenthionine/α-CD inclusion complex5.0123.5803.9413.5363.7853.859
Δδ0.0020.0010.0120.0010.0220.005