Journal of Food Bioactives, ISSN 2637-8752 print, 2637-8779 online
Journal website www.isnff-jfb.com

Original Research

Volume 28, December 2024, pages 50-58

Lenthionine, a key flavour compound of shiitake mushrooms, prevents platelet aggregation by inhibiting αIIbβ3 activation

Figures

Figure 1.
Figure 1. Schematic diagram of platelet activation by various types of agonists.
Figure 2.
Figure 2. Inhibitory effect of lenthionine on the platelet aggregation induced by A23187. Values are means ± SE of 3 different experiments.
Figure 3.
Figure 3. Flow cytometry of CD62P-phycoerythrin (PE) and PAC-1-fluorescein isothiocyanate (FITC) binding to platelets with and without lenthionine, before and after stimulation with various agonists.
Figure 4.
Figure 4. Scanning electron microscopy of platelets with and without lenthionine, before and after stimulation with A23187.
Figure 5.
Figure 5. Changes in the phosphorylation levels of (a) myosin light chain, (b) cofilin, (c) talin, and (d) α-actinin induced by A23187 with and without lenthionine. Values are means ± SE of 3 different experiments.