| Journal of Food Bioactives, ISSN 2637-8752 print, 2637-8779 online |
| Journal website www.isnff-jfb.com |
Review
Volume 17, March 2022, pages 6-10
Cinnamon: an immune modulator food additive to coronavirus
Table
| Phytocompounds | Chemical Formula | Molecular weight | Chemical Structure | Interaction with Coronavirus | Immune response |
|---|---|---|---|---|---|
| Cinnamaldehyde | C9H8O | 132.16 | | Spike Protein | TLR2 and TLR4 activation, NRF2 inducer, detoxify ROS/RNS, mitigate PI3K/Akt pathway |
| Eugenol | C10H12O2 | 164.20 | | Spike protein | Modulates NF-kB, IL-6, IL-1β and TNFα |
| Camphor | C10H16O | 152.23 | | Mpro of COVID-19 (Omar et al., 2020) | modulation of Nrf-2 and TLR4 (Salama et al., 2021) |
| Trans-cinnamyl acetate | C11H12O2 | 176.21 | | Binding with GLU471, ARG454, SER46 (Kulkarni et al., 2020) | inhibits the activity of NF-κB and the production of tumor necrosis factor alpha (TNFα-) induced interleukin-8 (IL-8) (Cabello et al., 2009) |
| Caryophyllene | C15H24 | 204.35 | | interactions with PHE 294. 3CLpro , NSP3, NSP9, and RDRP (Narkhede et al., 2020) | B cells, T cells, CD8+ lymphocytes, CD4+ lymphocytes, NK cells, neutrophils, macrophages, basophils, eosinophils, platelets, mast cells, dendritic cells, microglia, and astrocytes (Howlett and Abood, 2017; Jha et al., 2021) |