Journal of Food Bioactives, ISSN 2637-8752 print, 2637-8779 online
Journal website www.isnff-jfb.com

Review

Volume 2, Number , June 2018, pages 28-36

The origin of trimethylamine-N-oxide (TMAO) and its role in development of atherosclerosis

Figures

Figure 1.
Figure 1.

Production of TMAO from dietary TMA-containing components and metabolism of TMAO.

TMA, trimethylamine; TMAO, trimethylamine-N-oxide; FMOs, flavin monooxygenases. CntA/B, two-component Rieske-type oxygenase/reductase; CutC/D, choline TMA-lyase and its activating enzyme.
Figure 2.
Figure 2.

Effects of microbiota-dependent TMAO production on development of atherosclerosis.

TMA, trimethylamine; TMAO, trimethylamine-N-oxide; FMOs, flavin monooxygenases; RCT, reverse cholesterol transport.