Figure 1. Overview of tight junction proteins in enterocytes (Chiba et al., 2008; Michielan and D’Incà, 2015; Ulluwishewa et al., 2011).
Figure 2. Mechanism by which TNF-α modulates tight junctions in epithelial cells. Abbreviations: MLCK, myosin light-chain kinase; IKK, IκB kinase; IκBα, inhibitor of kappa B; TNFR: tumor necrosis factor receptor; TNF-α, tumor necrosis factor-α; ZO-1, zonula occludens-1; TEER, trans-epithelial electrical resistance. Adapted from Ulluwishewa et al. (2011) and Weber et al. (2010).