Antidiabetic effect of Melicope glabra¬ (Blume) T. G. Hartley (Rutaceae) in high-fat diet/streptozotocin-induced diabetic rats and its bioactive components

  • Alexandra Quek
  • Dai Chuan Tan
  • Pei Cee Lim
  • Nur Kartinee Kassim
  • Amin Ismail
  • Khozirah Shaari
  • Nuraisyah Mohd Shuib
DOI: https://doi.org/10.31665/JFB.2022.18320
Keywords: Antidiabetic, DPP-4, α-Amylase, Melicope glabra¬, GLP-1, Isolation, Hypoglycemic, Rutaceae

Abstract

Melicope glabra­ (Blume) T. G. Hartley is a plant of Rutaceae family. The present study aimed to evaluate the in vivo hypoglycemic effect of M. glabra leaves extract on diabetic rats and identify its bioactive components. The induction of diabetes in Sprague-Dawley rats was done by a combination of high-fat diet and low-dose streptozotocin injection. The M. glabra extracts and standard sitagliptin were orally administered once daily to the diabetic rats for 28 days. The diabetic rats showed drastic weight loss, hyperglycemia, poor glucose tolerance, hyperlipidemia, and disturbances in the liver and kidney functions. However, oral administration of M. glabra extracts to the diabetic rats significantly lowered the DPP-4 level and increased glucagon-like peptide-1 (GLP-1) level. Scopoletin, pachypodol, and stigmasterol were revealed as the active DPP-4 and α-amylase inhibitors. This study revealed novel findings which suggest the

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Published
2022-09-30
How to Cite
Quek , A., Tan, D. C., Lim , P. C., Kassim , N. K., Ismail, A., Shaari, K., & Shuib, N. M. (2022). Antidiabetic effect of Melicope glabra¬ (Blume) T. G. Hartley (Rutaceae) in high-fat diet/streptozotocin-induced diabetic rats and its bioactive components. Journal of Food Bioactives, 19. https://doi.org/10.31665/JFB.2022.18320
Issue
Vol 19 (2022)
Section
Original Research