Effectiveness of micellization with polysorbate 80 on the in vitro bioaccessibility of various bioactives

Bioaccessibility of bioactives from PS80 micelles

Abstract

The improvement in bioavailability of different compounds from PS80 micelles differs widely. This research, for the first time, investigated the effects bioactives, with different physicochemical properties (CoQ10, curcumin, catechin, naringenin, quercetin, β-carotene and retinyl palmitate), have on the micellar characteristics and the in vitro bioaccessibility of the loaded bioactives. There was no link between the physicochemical properties of the bioactives and the loading capacity of the PS80 micelles, which varied between 0.04 and 14.0%, or the average bioaccessibility of the bioactives, which varied between 14 and 86%. Not the ratio of loaded bioactive to PS80, but rather an increased concentration of PS80, increased the bioaccessibility of the loaded bioactive. It is not clear if differences were due to modifications of the PS80 micelles during the digestion process, where e.g. bile salts and/or phospholipids were incorporated into the micelles, or if the micelles totally dissociated and physiological mixed micelles were formed, including the PS80.